School of Medicine

Wayne State University School of Medicine

Alzheimer's Disease

Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest tasks. In most people with Alzheimer’s, symptoms first appear after the age 60. Estimates vary, but experts suggest that as many as 5.1 million Americans may have Alzheimer’s disease. In 2006, there were 26.6 million sufferers worldwide. Alzheimer's is predicted to affect 1 in 85 people globally by 2050.

The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. Current treatments only help with the symptoms of the disease. There are no available treatments that stop or reverse the progression of the disease. As of 2012, more than 1,000 clinical trials have been or are being conducted to test various compounds in AD.

Our Laboratory Investigates:

Quantification of tissue injury and the loss of cortical and grey matter tissue in patients with AD. In this context, we undertaking investigations in patients with AD that use novel imaging techniques such as DTI, MTR, MRS, gray matter segmentation and morphometric studies of the cortical gray matter.

Segmentation of White matter (in Red) from the whole brain tissue in T1-W image
Segmentation of Grey matter (in Red) from the whole brain tissue in T1-W image
Input image- 3D T1-weighted (MPRAGE, SPGR) image for cortical thickness measurement
Output Image- Segmented & parcellated conformed volume
Whole brain tissue- Axial diffusivity map of DTI
Whole brain tissue- Radial diffusivity map of DTI