School of Medicine

Wayne State University School of Medicine

CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).

Our Laboratory Investigates:.
 
Quantification of tissue injury in CADASIL patients and to quantify the disease progression are Magnetization Transfer Ratio (MTR), Diffusion Tensor Imaging (DTI) and  Magnetization Transfer Spectroscopy (MRS)
Evaluation of 6 X 6 matrixes on MTR map, DTI map and MRS is done to observe White Matter changes longitudinally.
1H-MRS CSI acquired in 6 X 6 matrixes to observe metabolite’s concentration changes

MTR map showing 6 X 6 matrix to observe White Matter changes

Whole brain tissue Magnetic Transfer ratio (MTR) map

Axial FLAIR image identifying the tissue damage in the white matter